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François Carreaux
Maître de conférences


E-mail
Tel : +(33) 2 23 23 57 34
Fax : +(33) 2 23 23 62 27

Web site

Parcours professionnel Educational Background

  • Assistant Professor of Chemistry, University of Rennes 1 (1994-Present)
  • Assistant Professor of Chemistry, Faculty of Pharmacy at the University of Paris V (1993-1994)
  • Postdoctoral fellow, Department of Chemistry, University of San Sebastian ES (1992-1993)
  • Ph.D Chemistry, University Pierre et Marie Curie (1988-1992)


Activités de recherche research Interests

  • Development of new strategies in organic chemistry

  • Synthesis of natural products and analogues

  • New inhibitors of protein kinases

  • Boron chemistry


Publications significatives relevant publications

  • Renault, S.; Bertrand, S.; Carreaux, F.; Bazureau, J. P. “Parallel Solution Phase Synthesis of 2-Alkylthio-5-Arylidene-3,5-dihydro-4H-imidazo-4-one by One-pot Three Component Tandem Reaction” J. Comb. Chem. 2007, under press.

  • Possémé, F.; Deligny, M.; Carreaux, F.; Carboni, B. “(E)-a-Substituted g-Alkoxyallylboronic Esters as New Reagents: Synthesis and Reactivity toward Aldehydes” J. Org. Chem. 2007, 72, 984.

  • Carreaux, F.; Favre, A.; Carboni, B.; Rouaud, I.; Boustie, J. “First Synthesis of (+)-8-methoxygoniodiol and its analogue, 8-deoxygoniodiol, using a three component strategy” Tetrahedron Lett. 2006, 47, 4545.

  • Gao, X.; Hall, D. G.; Deligny, M.;  Favre, A.; Carreaux, F.; Carboni, B. “Catalytic Enantioselective Three-Component Hetero-[4+2] Cycloaddition/Allylboration Approach to a-Hydroxyalkyl Pyrans : Scope, Limitations, and Mechanistical Proposal” Chem. Eur. J. 2006, 12, 3132.

  • Busnel, O.; Carreaux, F.; Carboni, B. ; Pethe, S. ; Vadon-Le Goff, S. ; Mansuy, D. ; Boucher, J.L. “Synthesis and Evaluation of new v-borono-a-amino acids as rat liver arginase inhibitors” Bioorg. Med. Chem. 2005, 13, 2373.

  • Chérouvrier, J-R.; Carreaux, F. ; Bazureau, J. P. “Microwave-mediated solventless synthesis of new derivatives of marine alkaloid Leucettamine B” Tetrahedron Lett. 2002, 43, 3581.

  • Carreaux, F.; Possémé, F.; Carboni, B.; Arrieta, A.; Lecea, B.; Cossio, F. P. “[4+3] versus [4+2] Mechanisms in the Dimerization of 2-Boryl-1,3-butadienes. A Theorical and Experimental Study” J. Org. Chem. 2002, 67, 9153.

  • Martin, B.; Possémé, F.; Le Barbier, C.; Carreaux, F. ; Carboni, B.; Seiler, N.; Moulinoux, J-P.; Delcros, J-G. “N-Benzylpolyamines as Vectors of Boron and Fluorine for Cancer Therapy and Imaging : Synthesis and Biological Evaluation” J. Med. Chem. 2001, 44, 3653.

  • Pourbaix, C.; Carreaux, F.; Carboni, B. “Metal-Catalyzed Release of Supported Boronic Acids for C-C Bond Formation” Org. Lett. 2001, 3, 803.

Responsabilités Responsabilities.

Equipe Ingénierie chimique et molécules pour le vivant, U.M.R. 6226 Sciences Chimiques de Rennes, Campus de Beaulieu, Bat. 10A, 10C, Avenue du Général Leclerc, 35042 RENNES Cedex, France;
CNRS
Univ