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Chercheurs CNRS Enseignants-Chercheurs ITA IATOS Ingénieurs non permanent Post-doctorant Doctorants Master 2 Départs

 

Bertrand Carboni
Directeur de recherche C.N.R.S


E-mail : bertrand.carboni@univ-rennes1.fr

Tel : +(33) 2 23 23 67 47

Fax : +(33) 2 23 23 62 27

Web site

CV

Directeur de Recherche CNRS 2ème classe, Rennes.

  • Ingénieur Ecole Nationale Supérieure de Chimie de Paris (1977)

  • Thèse de Docteur Ingénieur, Rennes (1980)

  • Ingénieur de Recherche, Rhône-Poulenc, Vitry sur Seine (1981-1983).

  • Thèse de Doctorat d’Etat, Rennes (1986).

  • Stage post-doctoral Pr. Giese, Bâle, (Sept. 1989 - Août 1990).

Activités de recherche Current research

  • Organoboron compounds in synthetic chemistry and biology,


  • Multicomponent reactions


  • Transition-metal mediated reactions and boronated enynes


  • Polymer-supported chemistry


  • Design and synthesis of new compounds targeting RNA.

Publications significatives relevant publications

  • V. Guerniou, R. Gillet, F. Berrée, B. Carboni, B. Felden Targeted degradation of the hepatitis C virus internal ribosome entry site genomic RNA with oligonucleotide conjugates, Nucleic Acid Research, 2007, 35, 6778-6787.

  • Hercouet, F. Berrée, C.H. Lin, B. Carboni, Boronated Enynes as Versatile Sources of Stereodefined and Skeletally Diverse Molecules, Org. Lett., 2007, 9, 1717-1720.

  • Possémé, M. Deligny, F.Carreaux, B. Carboni (E)-a-Substituted b-Alkoxyallylboronic Esters as New Reagents: Synthesis and Reactivity toward Aldehydes.J. Org. Chem., 2007, 72; 984-989.

  • T. Régnier, F. Berrée, O. Lavastre, B.Carboni, Solvent-Free One-Pot Four-Component Synthesis of Morpholine Derivatives. Access to Related Diaminoalcohols”, Green Chemistry., 2007, 66, 2449-2458.-

  • Debache, B. Boumoud, M. Amimour, A.Belfaitah,S. Rhouati, B. Carboni, Phenylboronic acid as a mild and efficient catalyst for Biginelli reaction, Tetrahedron Lett. , 2006, 47, 5697-5699.

  • X. Gao, D. Hall, M. Deligny, A. Favre, F. Carreaux, B. Carboni, Catalytic Enantioselective Three-Component Hetero-[4+2]Cycloaddition/Allylboration Approach to a-Hydroxyalkyl Pyrans: Scope, Limitations, Mechanistic Proposal, Chemistry, Eur. J ., 2006, 12, 3132-3142.

  • E. Bustelo, C. Guerot, A. Hercouet, B. Carboni, L. Toupet, P. H. Dixneuf. An Opened Route to 1,3-Dimethylenecyclobutanes via Sequential Ruthenium-Catalyzed [2+2] Cycloaddition of Allenyl Boronate and Palladium Suzuki Coupling, J. Am. Chem. Soc .,2005, 127, 11581-11582

  • Deligny, M.; Carreaux, F.; Carboni, B. A Concise Synthesis of (+)-Goniodiol using a Catalytic Hetero Diels-Alder/Allylboration sequence, Synlett, 2005, 1462.

  • Busnel,O.; Carreaux, F.; Carboni, B.; Pethe, S.; Vadon-Le Goff, S.; Mansuy, D.; Boucher, J-L.; Synthesis and evaluation of new w-borono-a-amino acids as rat liver arginase inhibitors, Bio. Org. Med. Chem. , 2005, 13, 2373-2379.

  • Hercouet, A.; Baudet C.; Carboni, B.; Synthesis of new boron analogues of cyclic carboxylic a-amino acids using ring-closing metathesis reactions, Tetrahedron Lett. 2004, 45 , 8749-8751

  • Fouace, S.; Gaudin, C.; Picard,, S.; Corvaisier, S.; Renault, J.; Carboni, B.; Felden, B. New Polyamine Derivatives as Selective RNaseA Mimics Nucleic Acid Research ., 2004, 32, 151-157

  • Deligny, M.; Carreaux, F.; Toupet, L.; Carboni, B. Highly Diastereo- and Enantioselective Synthesis of 2,6-Disubstituted 2H-Dihydropyrans via a Catalytic Asymmetric Hetero-Diels-Alder/Allylboration Sequence, Adv Synt. Cat, , 2003, 345 , 1215-1219.

  • Touzani, R.; Garbacia, S.; Lavastre, O.; Yadav, V.K.; Carboni, B. An Efficient Solution Phase Combinatorial Access To Libraries of Pyrazole and Triazole- Containing Compounds, J. Comb. Chem. , 2003 , 5, 375-378.

  • Deligny, M., Carreaux, F., Carboni, B., Toupet, L., Dujardin, G. A novel stereoselective route to ?-hydroxyalkyl dihydropyrans using an hetero-Diels-Alder/allylboration sequence, Chem. Comm. , 2003, 276.

  • Carreaux, F., Possémé, F., Carboni, B., Arrietab, A., Leceac, B., Cossío, F., [4+3] versus [4+2] Mechanisms in the Dimerization of 2-boryl-1,3-butadienes. A Theoretical and Experimental Study, J. Org. Chem. , 2002 , 67, 9153-9161.

  • Martin, B., Possémé, F.; Le Barbier, C.; Carreaux, F.; Carboni, B.; Seiler, N.; Moulinoux, J.P.; Delcros, J.G., (Z)-1,4-diamino-2-butene as a Vector of Boron, Fluorine, or Iodine for Cancer Therapy and Imaging: Synthesis and Biological Evaluation, Bio. Org. Med. Chem. Lett. , 2002 , 12,.2863-2871.

  • Thormeier, S., Carboni, B., Kaufmann, D. Chiral Boronates – Versatile Reagents in Asymmetric Synthesis J. Organomet. Chem. , 2002,.657 (1),136-145.

  • Possémé, F.; Le Barbier, C.; Carreaux, F.; Carboni, B.; Seiler, N.; Moulinoux, J.P.; Delcros, J.G., Martin, B., Benzyl-polyamines as Vectors of Boron and Fluorine for Cancer Therapy and Imaging. Synthesis and Biological Evaluation. J. Med. Chem. , 2001 , 44, 3653-3664.

  • Rastelli, A.; Gandolfi, R.; Sarzi-Amade, M.; Carboni, B. Modeling the 1,3-dipolar cycloaddition of nitrones to vinylboranes in competition with boration, cyclization, and oxidation reactions reactions J. Org. Chem. , 2001 , 66, 2449-2458.

  • Pourbaix, C.; Carreaux, F.; Carboni, Metal-Catalyzed Release of Supported Boronic Acids for C-C Bond Formation, Org. Lett. ,2001 , 803-805.

  • Carmes, L.; Carreaux, F.; Carboni, B. Homologation of Boronic Esters with (Dialkoxymethyl)lithiums. Asymmetric Synthesis of a-Alkoxy Boronic Esters J. Org. Chem. , 2000, 65 ,5403-5408.

  • Hercouet, A.; Le Corre, M.; Carboni, B. Asymmetric Synthesis of a phosphonic analogue of (-)-allo-norcoronamic acid, Tetrahedron Lett. , 2000, 41, 197-199.

Chapitres de livre Book Chapters.

  • B. CARBONI, F. CARREAUX, Aminoboranes and amine-Borane Complexes, Houben Weyl,  Science of Synthesis,, Vol 6, Boron Compounds, Georg Thieme Verlag, New York, Dec 2004, pp 455-484.

  • A.C. GAUMONT, B. CARBONI, Phosphinoboranes and Phosphine-BoraneComplexes, Houben Weyl,  Science of Synthesis,, Vol 6, Boron Compounds, Georg Thieme Verlag, New York, Dec 2004, pp 485-512.

  • B. CARBONI, F. CARREAUX, Cycloadditions and other additions to alkenyl- and dienylboronates in Boronic Acids in Organic Synthesis and Chemical Biology, Wiley-VCH, 2005, pp 343-376
Equipe Ingénierie chimique et molécules pour le vivant, U.M.R. 6226 Sciences Chimiques de Rennes, Campus de Beaulieu, Bat. 10A, 10C, Avenue du Général Leclerc, 35042 RENNES Cedex, France;
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